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Structure-activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids.
Boonruang S, Prakobsri K, Pouyfung P, Prasopthum A, Rongnoparut P, Sarapusit S. Boonruang S, et al. Xenobiotica. 2020 Jun;50(6):630-639. doi: 10.1080/00498254.2019.1675101. Epub 2019 Oct 14. Xenobiotica. 2020. PMID: 31578905
Cigarette smoking is one of the major risk factors of various diseases including respiratory diseases and lung cancer. While the liver-specific CYP2A6 is associated with the nicotine clearance and smoking addiction, the metabolic activation of the tobacco-spe …
Cigarette smoking is one of the major risk factors of various diseases including respiratory diseases and lung cancer. While t …
Newly Identified Tree Shrew Cytochrome P450 2A13 is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog Cytochrome P450 2A13 and Pig Cytochrome P450 2A19.
Ushirozako G, Noda Y, Murayama N, Kawaguchi H, Tsukiyama-Kohara K, Yamazaki H, Uno Y. Ushirozako G, et al. Drug Metab Dispos. 2023 May;51(5):610-617. doi: 10.1124/dmd.122.001152. Epub 2023 Jan 20. Drug Metab Dispos. 2023. PMID: 36669854
Among the tissue types analyzed, tree shrew CYP2A13 mRNA was preferentially expressed in liver and lung, similar to dog CYP2A13 mRNA, whereas dog CYP2A25 and pig CYP2A19 mRNAs were predominantly expressed in liver. ...Tree shrew CYP2A13 isolated …
Among the tissue types analyzed, tree shrew CYP2A13 mRNA was preferentially expressed in liver and lung, similar to dog CYP …
Metabolism of Scoparone in Experimental Animals and Humans.
Juvonen RO, Novák F, Emmanouilidou E, Auriola S, Timonen J, Heikkinen AT, Küblbeck J, Finel M, Raunio H. Juvonen RO, et al. Planta Med. 2019 Apr;85(6):453-464. doi: 10.1055/a-0835-2301. Epub 2019 Feb 8. Planta Med. 2019. PMID: 30736072
We evaluated in detail the metabolism of scoparone in human, mouse, rat, pig, dog, and rabbit liver microsomes in vitro and in humans in vivo. Oxidation of scoparone to isoscopoletin via 6-O-demethylation was the major metabolic pathway in liver microsomes from huma …
We evaluated in detail the metabolism of scoparone in human, mouse, rat, pig, dog, and rabbit liver microsomes in vitro and in humans …
The CYP2A subfamily: function, expression and genetic polymorphism.
Raunio H, Rautio A, Pelkonen O. Raunio H, et al. IARC Sci Publ. 1999;(148):197-207. IARC Sci Publ. 1999. PMID: 10493259 Review.
The CYP2A6 gene is one of the three members of the human CYP2A gene subfamily, the others being CYP2A7 and CYP2A13. The CYP2A6 enzyme catalyses the oxidation of several compounds that have clinical or toxicological interest, including pharmaceuticals, procarcinogens, and t …
The CYP2A6 gene is one of the three members of the human CYP2A gene subfamily, the others being CYP2A7 and CYP2A13. The CYP2A6 enzyme …
Inhibition of human cytochromes P450 2A6 and 2A13 by flavonoids, acetylenic thiophenes and sesquiterpene lactones from Pluchea indica and Vernonia cinerea.
Boonruang S, Prakobsri K, Pouyfung P, Srisook E, Prasopthum A, Rongnoparut P, Sarapusit S. Boonruang S, et al. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1136-1142. doi: 10.1080/14756366.2017.1363741. J Enzyme Inhib Med Chem. 2017. PMID: 28856944 Free PMC article.
The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism and activation of tobacco-specific nitrosamine carcinogens. Inhibition of both enzymes could offer a strategy for smoking abstinence and decreased risks of …
The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism and activation …
Cytochrome P450 2A13 mediates aflatoxin B1-induced cytotoxicity and apoptosis in human bronchial epithelial cells.
Yang XJ, Lu HY, Li ZY, Bian Q, Qiu LL, Li Z, Liu Q, Li J, Wang X, Wang SL. Yang XJ, et al. Toxicology. 2012 Oct 28;300(3):138-48. doi: 10.1016/j.tox.2012.06.010. Epub 2012 Jun 26. Toxicology. 2012. PMID: 22743290
To achieve these objectives, CYP2A13 was stably over-expressed in immortalized human bronchial epithelial BEAS-2B cells (B-2A13) and its significance in AFB(1)-induced cytotoxicity, DNA adducts, and apoptosis was compared to cells with stably expression of CYP1A2 (B-1A2), …
To achieve these objectives, CYP2A13 was stably over-expressed in immortalized human bronchial epithelial BEAS-2B cells (B-2A13) and …